![]() This nonoral route of administration for pain medication has the potential benefit, in theory, of local activity and fewer systemic side effects. One such strategy is to expand use of topical pain medications-medications applied to intact skin. In recent years, the issues surrounding the complexity of pain management have contributed to increased demand for alternative strategies for treating pain. In terms of pain’s global impact, estimates suggest the problem affects approximately 1 in 5 adults across the world, with nearly 1 in 10 adults newly diagnosed with chronic pain each year. The impact of pain at a population level is vast and, while estimates differ, the Centers for Disease Control and Prevention reported that 50 million U.S. Physical, social, economic, and emotional consequences of pain can impair an individual’s overall health, well-being, productivity, and relationships in myriad ways. It manifests in multiple forms and its treatment is complex.
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